AIM1. DISCOVERY OF MECHANISMS AND TREATMENTS THAT PROTECT MITOCHONDRIA FROM COPPER TOXICITY
Sub-aim 1A. Screening for sub-population of mitochondria with particular sensitivity to Cu toxicity.
Sub-aim 1B. Identification and validation of molecular targets that increase resistance of mitochondria to Cu in WD.
Sub-aim 1C. Validation of mitochondria-specific drugs that induce tolerance to Cu overload in WD.
AIM2. IDENTIFICATION OF MECHANISMS THAT REDUCE COPPER TOXICITY THROUGH TURNOVER OF DAMAGED MITOCHONDRIA
Sub-aim 2A. Evaluation of mitophagy as potential protective mechanism in WD.
Sub-aim 2B. High throughput screenings for gene targets and drugs, facilitating survival of ATP7B deficient cells through mitochondrial and/or mitophagic pathways
Sub-aim 2C. Validation of mitochondria/mitophagy-associated gene targets and drugs in animal models of WD
Deadline 30/11/2021
Programme ACCORDI BILATERALI CNR/RFBR triennio 2018-2020 2018-2020
Institute IBBR – Institute of Biosciences and Bioresources
Contact Elia Di Schiavi elia.dischiavi@ibbr.cnr.it
Link https://www.cnr.it/it/accordi-bilaterali/progetto/3065/identificazione-di-nuove-molecole-aventi-come-bersaglio-i-mitocondri-per-proteggere-dagli-effetti-tossici-del-rame
Role Coordinatore