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12
Mar

A network-biology based approach for the development of SMN-independent treatments

2021-03-12
Here, we propose a network-biology based approach to detect and test SMN-independent treatment options. The approval of Spinraza has been a milestone for the treatment of SMA the last years. However, still there are a number of non-responders and many patients have been symptomatic for years. This is a significant problem since a delayed intervention...
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12
Mar

CalMarSi LIFE – Measures of integrated conservation of Calendula maritima Guss., a rare threatened plant of the Sicilian vascular flora

2021-03-12
Calendula maritima Guss. is a herbaceous plant species, with annual or short perennial life cycle depending on water availability as well as on the intensity and length of summer water stress. It plays a key functional role within a variety of coastal ecosystems, even affecting their physiognomy. Currently it often takes part to nitrophilous and...
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12
Mar

ELUCIDATION OF NITRIC OXIDE SIGNALLING IN PLANTS THROUGH NOVEL GENETICALLY ENCODED FLUORESCENT SENSORS

2021-03-12
O is a gaseous signalling molecule with fundamental physiological roles in animals and plants. In plants, NO participates broadly in several developmental processes and in biotic and abiotic stress responses. Despite its importance, the questions of where and how NO is synthesized, how it is redistributed across plant cells or tissues, and even how it...
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12
Mar

Identificazione di nuove molecole aventi come bersaglio i mitocondri per proteggere dagli effetti tossici del rame

2021-03-12
AIM1. DISCOVERY OF MECHANISMS AND TREATMENTS THAT PROTECT MITOCHONDRIA FROM COPPER TOXICITY Sub-aim 1A. Screening for sub-population of mitochondria with particular sensitivity to Cu toxicity. Sub-aim 1B. Identification and validation of molecular targets that increase resistance of mitochondria to Cu in WD. Sub-aim 1C. Validation of mitochondria-specific drugs that induce tolerance to Cu overload in...
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27
Feb

NANOTOM – Conversion of natural plant nanovesicles into nutraceutical delivery system

2021-02-27
Novel encapsulation approaches to create alternative delivery options for nutraceuticals are emerging as a promising strategy to enhance the bioavailability of poorly absorbed active food ingredients. In this context, nanoTOM aims to exploit edible plant derived nanovesicles and use them as vehicles for the encapsulation, protection, release and bioavailability enhancement of selected nutraceuticals. Plant cells...
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